Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC3129449 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Li Dongdong D Herrera Stacy S Bubula Nancy N Nikitina Elena E Palmer Abraham A AA Hanck Dorothy A DA Loweth Jessica A JA Vezina Paul P
Journal of neurochemistry 20110606 2
The closely related δ and ε isoforms of the serine/threonine protein kinase casein kinase 1 (Csnk1) have been implicated in the generation of psychostimulant-induced behaviors. In this study, we show that Csnk1δ/ε produces its effects on behavior by acting on the Darpp-32-PP1 signaling pathway to regulate AMPA receptor phosphorylation in the nucleus accumbens (NAcc). Inhibiting Csnk1δ/ε in the NAcc with the selective inhibitor PF-670462 blocks amphetamine induced locomotion and its ability to in ...[more]