Ontology highlight
ABSTRACT:
SUBMITTER: Mukasa R
PROVIDER: S-EPMC3129685 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Mukasa Ryuta R Balasubramani Anand A Lee Yun Kyung YK Whitley Sarah K SK Weaver Benjamin T BT Shibata Yoichiro Y Crawford Gregory E GE Hatton Robin D RD Weaver Casey T CT
Immunity 20100513 5
Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. We identified epigenetic modifications across the clustered Il17a and Il17f and the Ifng loci before and after differential IL-12 or TGF-beta cytokine signaling, which induce divergent fates of Th17 cell precursors. We found that Th17 cell precursors had substantial remodeling of the Ifng locus, but underwent critical additional modifications to enable high expression when ...[more]