Pharmacodynamics of a novel designer natriuretic peptide, CD-NP, in a first-in-human clinical trial in healthy subjects.
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ABSTRACT:
SUBMITTER: Lee CY
PROVIDER: S-EPMC3129694 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
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Pharmacodynamics of a novel designer natriuretic peptide, CD-NP, in a first-in-human clinical trial in healthy subjects.
Lee Candace Y W CY Chen Horng H HH Lisy Ondrej O Swan Suzanne S Cannon Courtney C Lieu Hsiao D HD Burnett John C JC
Journal of clinical pharmacology 20090424 6
CD-NP is a novel chimeric natriuretic peptide (NP) consisting of the 22-amino-acid (AA) human C-type natriuretic peptide (CNP), a venodilating peptide with limited renal actions and minimal effects on blood pressure, and the 15-AA C-terminus of Dendroaspis NP (DNP). The rationale for the design of CD-NP was to enhance the renal actions of CNP, the ligand for natriuretic peptide receptor-B, but without inducing excessive hypotension. Here we report the first-in-human studies for CD-NP, which repr ...[more]
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