Ontology highlight
ABSTRACT:
SUBMITTER: Adami RC
PROVIDER: S-EPMC3129796 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Adami Roger C RC Seth Shaguna S Harvie Pierrot P Johns Rachel R Fam Renata R Fosnaugh Kathy K Zhu Tianying T Farber Ken K McCutcheon Michael M Goodman Thomas T TT Liu Yan Y Chen Yan Y Kwang Erin E Templin Michael V MV Severson Greg G Brown Tod T Vaish Narendra N Chen Feng F Charmley Patrick P Polisky Barry B Houston Michael E ME
Molecular therapy : the journal of the American Society of Gene Therapy 20110419 6
We demonstrate a systematic and rational approach to create a library of natural and modified, dialkylated amino acids based upon arginine for development of an efficient small interfering RNA (siRNA) delivery system. These amino acids, designated DiLA₂ compounds, in conjunction with other components, demonstrate unique properties for assembly into monodisperse, 100-nm small liposomal particles containing siRNA. We show that DiLA₂-based liposomes undergo a pH-dependent phase transition to an inv ...[more]