Ontology highlight
ABSTRACT:
SUBMITTER: Moreira RP
PROVIDER: S-EPMC3129971 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Moreira Ricardo P P RP Jorge Alexander A L AA Mendonca Berenice B BB Bachega Tânia A S S TA
Clinics (Sao Paulo, Brazil) 20110101 6
<h4>Introduction</h4>PXR polymorphisms have been implicated in modulating CYP3A4 and PXR expression, potentially accounting for interindividual differences in drug metabolism. The prevalence of PXR polymorphisms varies among ethnic groups and data on the allelic distribution in the highly mixed Brazilian population is lacking. The aim of this study was to analyze genetic variations in the PXR gene in Brazilians and to compare the results to other ethnic groups.<h4>Methods</h4>DNA samples from 11 ...[more]