Ontology highlight
ABSTRACT:
SUBMITTER: Lasek AW
PROVIDER: S-EPMC3130015 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Lasek A W AW Kapfhamer D D Kharazia V V Gesch J J Giorgetti F F Heberlein U U
Genes, brain, and behavior 20100812 7
An estimated 2 million Americans use cocaine, resulting in large personal and societal costs. Discovery of the genetic factors that contribute to cocaine abuse is important for understanding this complex disease. Previously, mutations in the Drosophila LIM-only (dLmo) gene were identified because of their increased behavioral sensitivity to cocaine. Here we show that the mammalian homolog Lmo4, which is highly expressed in brain regions implicated in drug addiction, plays a similar role in cocai ...[more]