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A novel form of oxytocin in New World monkeys.

ABSTRACT: Oxytocin is widely believed to be present and structurally identical in all placental mammals. Here, we report that multiple species of New World monkeys possess a novel form of oxytocin, [P8] oxytocin. This mutation arises from a substitution of a leucine to a proline in amino acid position 8. Further analysis of this mutation in Saimiri sciureus (squirrel monkey) indicates that [P8] oxytocin is transcribed and translated properly. This mutation is specific to oxytocin, as the peptide sequence for arginine vasopressin, a structurally related nonapeptide, is unaltered. These findings dispel the notion that all placental mammals possess a 'universal' oxytocin sequence, and highlight the need for research on the functional significance of this novel nonapeptide in New World monkeys.

SUBMITTER: Lee AG

PROVIDER: S-EPMC3130245 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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A novel form of oxytocin in New World monkeys.

Lee Alex G AG Cool David R DR Grunwald William C WC Neal Donald E DE Buckmaster Christine L CL Cheng Michelle Y MY Hyde Shellie A SA Lyons David M DM Parker Karen J KJ

Biology letters 20110316 4

Oxytocin is widely believed to be present and structurally identical in all placental mammals. Here, we report that multiple species of New World monkeys possess a novel form of oxytocin, [P8] oxytocin. This mutation arises from a substitution of a leucine to a proline in amino acid position 8. Further analysis of this mutation in Saimiri sciureus (squirrel monkey) indicates that [P8] oxytocin is transcribed and translated properly. This mutation is specific to oxytocin, as the peptide sequence ...[more]

PMID: 21411453

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