Ontology highlight
ABSTRACT:
SUBMITTER: Berkhout B
PROVIDER: S-EPMC3130279 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Berkhout Ben B Arts Kelly K Abbink Truus E M TE
Nucleic acids research 20110309 12
Translation initiation on most eukaryotic mRNAs occurs via a cap-dependent scanning mechanism and its efficiency is modulated by their 5'-untranslated regions (5'-UTR). The human immunodeficiency virus type 1 (HIV-1) 5'-UTR contains a stable TAR hairpin directly at its 5'-end, which possibly masks the cap structure. In addition, the 5'-UTR is relatively long and contains several stable RNA structures that are essential for viral replication. These characteristics may interfere with ribosomal sca ...[more]