Transcriptional regulation via TF-modifying enzymes: an integrative model-based analysis.
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ABSTRACT:
SUBMITTER: Everett LJ
PROVIDER: S-EPMC3130287 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Transcriptional regulation via TF-modifying enzymes: an integrative model-based analysis.
Everett Logan J LJ Jensen Shane T ST Hannenhalli Sridhar S
Nucleic acids research 20110405 12
Transcription factor activity is largely regulated through post-translational modification. Here, we report the first integrative model of transcription that includes both interactions between transcription factors and promoters, and between transcription factors and modifying enzymes. Simulations indicate that our method is robust against noise. We validated our tool on a well-studied stress response network in yeast and on a STAT1-mediated regulatory network in human B cells. Our work represen ...[more]
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