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Optical coherence tomography for the quantitative study of cerebrovascular physiology.

ABSTRACT: Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

SUBMITTER: Srinivasan VJ

PROVIDER: S-EPMC3130321 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Optical coherence tomography for the quantitative study of cerebrovascular physiology.

Srinivasan Vivek J VJ Atochin Dmitriy N DN Radhakrishnan Harsha H Jiang James Y JY Ruvinskaya Svetlana S Wu Weicheng W Barry Scott S Cable Alex E AE Ayata Cenk C Huang Paul L PL Boas David A DA

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110302 6

Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion ov ...[more]

PMID: 21364599

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