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Targeted treatment of recurrent platinum-resistant ovarian cancer: current and emerging therapies.

ABSTRACT: With advances in surgical techniques and chemotherapeutic agents, mortality rates from epithelial ovarian cancer (EOC) have slightly decreased over the last 30 years. However, EOC still ranks as the most deadly gynecologic cancer with an overall 5-year survival rate of 45%. Prognosis is especially disappointing for women with platinum-resistant disease, where 80% of patients will fail to respond to available therapies. Emerging treatment strategies have sub-sequently focused on targets which are integral to tumor growth and metastasis. In this review, we will focus on those innovative agents currently under investigation in clinical trials.

SUBMITTER: Mantia-Smaldone GM

PROVIDER: S-EPMC3130354 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Targeted treatment of recurrent platinum-resistant ovarian cancer: current and emerging therapies.

Mantia-Smaldone Gina M GM Edwards Robert P RP Vlad Anda M AM

Cancer management and research 20101230

With advances in surgical techniques and chemotherapeutic agents, mortality rates from epithelial ovarian cancer (EOC) have slightly decreased over the last 30 years. However, EOC still ranks as the most deadly gynecologic cancer with an overall 5-year survival rate of 45%. Prognosis is especially disappointing for women with platinum-resistant disease, where 80% of patients will fail to respond to available therapies. Emerging treatment strategies have sub-sequently focused on targets which are ...[more]

PMID: 21734812

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