Ontology highlight
ABSTRACT:
SUBMITTER: Nagai Y
PROVIDER: S-EPMC3131094 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Nagai Yoshio Y Yonemitsu Shin S Erion Derek M DM Iwasaki Takanori T Stark Romana R Weismann Dirk D Dong Jianying J Zhang Dongyan D Jurczak Michael J MJ Löffler Michael G MG Cresswell James J Yu Xing Xian XX Murray Susan F SF Bhanot Sanjay S Monia Brett P BP Bogan Jonathan S JS Samuel Varman V Shulman Gerald I GI
Cell metabolism 20090301 3
Peroxisome proliferator-activated receptor gamma coactivator-1 beta (PGC-1beta) is known to be a transcriptional coactivator for SREBP-1, the master regulator of hepatic lipogenesis. Here, we evaluated the role of PGC-1beta in the pathogenesis of fructose-induced insulin resistance by using an antisense oligonucletoide (ASO) to knockdown PGC-1beta in liver and adipose tissue. PGC-1beta ASO improved the metabolic phenotype induced by fructose feeding by reducing expression of SREBP-1 and downstre ...[more]