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Comparative functional genomics of the fission yeasts.


ABSTRACT: The fission yeast clade--comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus--occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.

SUBMITTER: Rhind N 

PROVIDER: S-EPMC3131103 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Comparative functional genomics of the fission yeasts.

Rhind Nicholas N   Chen Zehua Z   Yassour Moran M   Thompson Dawn A DA   Haas Brian J BJ   Habib Naomi N   Wapinski Ilan I   Roy Sushmita S   Lin Michael F MF   Heiman David I DI   Young Sarah K SK   Furuya Kanji K   Guo Yabin Y   Pidoux Alison A   Chen Huei Mei HM   Robbertse Barbara B   Goldberg Jonathan M JM   Aoki Keita K   Bayne Elizabeth H EH   Berlin Aaron M AM   Desjardins Christopher A CA   Dobbs Edward E   Dukaj Livio L   Fan Lin L   FitzGerald Michael G MG   French Courtney C   Gujja Sharvari S   Hansen Klavs K   Keifenheim Dan D   Levin Joshua Z JZ   Mosher Rebecca A RA   Müller Carolin A CA   Pfiffner Jenna J   Priest Margaret M   Russ Carsten C   Smialowska Agata A   Swoboda Peter P   Sykes Sean M SM   Vaughn Matthew M   Vengrova Sonya S   Yoder Ryan R   Zeng Qiandong Q   Allshire Robin R   Baulcombe David D   Birren Bruce W BW   Brown William W   Ekwall Karl K   Kellis Manolis M   Leatherwood Janet J   Levin Henry H   Margalit Hanah H   Martienssen Rob R   Nieduszynski Conrad A CA   Spatafora Joseph W JW   Friedman Nir N   Dalgaard Jacob Z JZ   Baumann Peter P   Niki Hironori H   Regev Aviv A   Nusbaum Chad C  

Science (New York, N.Y.) 20110421 6032


The fission yeast clade--comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus--occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for  ...[more]

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