Ontology highlight
ABSTRACT:
SUBMITTER: Simoes Sde M
PROVIDER: S-EPMC3131216 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Simões Sérgio de Matos Sde M Blankenship J Todd JT Weitz Ori O Farrell Dene L DL Tamada Masako M Fernandez-Gonzalez Rodrigo R Zallen Jennifer A JA
Developmental cell 20100901 3
Cell rearrangements shape the Drosophila embryo via spatially regulated changes in cell shape and adhesion. We show that Bazooka/Par-3 (Baz) is required for the planar polarized distribution of myosin II and adherens junction proteins and polarized intercalary behavior is disrupted in baz mutants. The myosin II activator Rho-kinase is asymmetrically enriched at the anterior and posterior borders of intercalating cells in a pattern complementary to Baz. Loss of Rho-kinase results in expansion of ...[more]