Ontology highlight
ABSTRACT:
SUBMITTER: Sohn I
PROVIDER: S-EPMC3131260 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Sohn Insuk I Owzar Kouros K Lim Johan J George Stephen L SL Mackey Cushman Stephanie S Jung Sin-Ho SH
BMC bioinformatics 20110526
<h4>Background</h4>A key objective in many microarray association studies is the identification of individual genes associated with clinical outcome. It is often of additional interest to identify sets of genes, known a priori to have similar biologic function, associated with the outcome.<h4>Results</h4>In this paper, we propose a general permutation-based framework for gene set testing that controls the false discovery rate (FDR) while accounting for the dependency among the genes within and a ...[more]