CD39/adenosine pathway is involved in AIDS progression.
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ABSTRACT:
SUBMITTER: Nikolova M
PROVIDER: S-EPMC3131268 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
CD39/adenosine pathway is involved in AIDS progression.
Nikolova Maria M Carriere Matthieu M Jenabian Mohammad-Ali MA Limou Sophie S Younas Mehwish M Kök Ayrin A Huë Sophie S Seddiki Nabila N Hulin Anne A Delaneau Olivier O Schuitemaker Hanneke H Herbeck Joshua T JT Mullins James I JI Muhtarova Maria M Bensussan Armand A Zagury Jean-François JF Lelievre Jean-Daniel JD Lévy Yves Y
PLoS pathogens 20110707 7
HIV-1 infection is characterized by a chronic activation of the immune system and suppressed function of T lymphocytes. Regulatory CD4+ CD25(high) FoxP3+CD127(low) T cells (Treg) play a key role in both conditions. Here, we show that HIV-1 positive patients have a significant increase of Treg-associated expression of CD39/ENTPD1, an ectoenzyme which in concert with CD73 generates adenosine. We show in vitro that the CD39/adenosine axis is involved in Treg suppression in HIV infection. Treg inhib ...[more]
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