Ontology highlight
ABSTRACT:
SUBMITTER: Lucks JB
PROVIDER: S-EPMC3131332 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Lucks Julius B JB Mortimer Stefanie A SA Trapnell Cole C Luo Shujun S Aviran Sharon S Schroth Gary P GP Pachter Lior L Doudna Jennifer A JA Arkin Adam P AP
Proceedings of the National Academy of Sciences of the United States of America 20110603 27
New regulatory roles continue to emerge for both natural and engineered noncoding RNAs, many of which have specific secondary and tertiary structures essential to their function. Thus there is a growing need to develop technologies that enable rapid characterization of structural features within complex RNA populations. We have developed a high-throughput technique, SHAPE-Seq, that can simultaneously measure quantitative, single nucleotide-resolution secondary and tertiary structural information ...[more]