Non-canonical ?-catenin degradation mediates reactive oxygen species-induced epidermal cell death.
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ABSTRACT:
SUBMITTER: Omori E
PROVIDER: S-EPMC3131442 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Non-canonical β-catenin degradation mediates reactive oxygen species-induced epidermal cell death.
Omori E E Matsumoto K K Ninomiya-Tsuji J J
Oncogene 20110307 30
β-Catenin is constantly degraded through the ubiquitin-proteasomal pathway. In this study, we report that a different type of β-catenin degradation is causally involved in epidermal cell death. We observed that reactive oxygen species (ROS) caused β-catenin degradation in the epidermal cells through a caspase-dependent mechanism, which results in disruption of cell adhesion. Disruption of cell adhesion increased ROS and activated caspases. Upregulation of the intact β-catenin blocked ROS accumul ...[more]
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