Ontology highlight
ABSTRACT:
SUBMITTER: Ponder EL
PROVIDER: S-EPMC3131532 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Ponder Elizabeth L EL Albrow Victoria E VE Leader Brittany A BA Békés Miklós M Mikolajczyk Jowita J Fonović Urša Pečar UP Shen Aimee A Drag Marcin M Xiao Junpeng J Deu Edgar E Campbell Amy J AJ Powers James C JC Salvesen Guy S GS Bogyo Matthew M
Chemistry & biology 20110601 6
Small ubiquitin-related modifier (SUMO) is implicated in the regulation of numerous biological processes including transcription, protein localization, and cell cycle control. Protein modification by SUMO is found in Plasmodium falciparum; however, its role in the regulation of the parasite life cycle is poorly understood. Here we describe functional studies of a SUMO-specific protease (SENP) of P. falciparum, PfSENP1 (PFL1635w). Expression of the catalytic domain of PfSENP1 and biochemical prof ...[more]