Ontology highlight
ABSTRACT:
SUBMITTER: Zeng HZ
PROVIDER: S-EPMC3131574 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Zeng Hua-Zong HZ Qu Yi-Qing YQ Zhang Wen-Jun WJ Xiu Bing B Deng An-Mei AM Liang Ai-Bin AB
International journal of molecular sciences 20110601 6
The aim of study is to identify cisplatin-resistance associated biomarkers for non-small cell lung cancers (NSCLC). We use two-dimensional electrophoresis (2-DE) combined with MALDI-TOF mass spectrometry to compare the proteome between lung cancer cell line A549 and its cisplatin-resistant subline A549/DDP. Nine cisplatin resistance-related proteins were identified, and DJ-1, one of the differently expressed proteins, was selected for further validation and evaluation. Immunohistochemical result ...[more]