Ontology highlight
ABSTRACT:
SUBMITTER: Gheinani AH
PROVIDER: S-EPMC3131675 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Gheinani Ali Hashemi AH Jahromi Neda Haghayegh NH Feuk-Lagerstedt Elisabeth E Taherzadeh Mohammad J MJ
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research 20110620
Rhizopus oryzae is a filamentous fungus, belonging to the order Mucorales. It can ferment a wide range of carbohydrates hydrolyzed from lignocellulosic materials and even cellobiose to produce ethanol. However, R. oryzae also produces lactic acid as a major metabolite, which reduces the yield of ethanol. In this study, we show that significant reduction of lactic acid production could be achieved by short (25nt) synthetic siRNAs targeting the ldhA gene. The average yield of lactic acid productio ...[more]