The extended PP1 toolkit: designed to create specificity.
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ABSTRACT:
SUBMITTER: Bollen M
PROVIDER: S-EPMC3131691 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
The extended PP1 toolkit: designed to create specificity.
Bollen Mathieu M Peti Wolfgang W Ragusa Michael J MJ Beullens Monique M
Trends in biochemical sciences 20100501 8
Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein dephosphorylation reactions in a highly regulated and selective manner. Recent studies have identified an unusually diversified PP1 interactome with the properties of a regulatory toolkit. PP1-interacting proteins (PIPs) function as targeting subunits, substrates and/or inhibitors. As targeting subunits, PIPs contribute to substrate selection by bringing PP1 into the vicinity of specific substrates and by modulating ...[more]
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