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Human endogenous retroviruses in multiple sclerosis: potential for novel neuro-pharmacological research.

ABSTRACT: There is growing evidence that the env genes of two or more human endogenous retroviruses (HERVs) of the W family are contributing to the inflammatory processes, and thus to the pathogenesis, of multiple sclerosis (MS). Increasing understanding of the human endogenous retroviral locus, ERVWE1, and the putative multiple sclerosis associated retrovirus, or MSRV, and in particular of the HERV-W env sequences associated with these, offers the potential of new lines of pharmacological research that might assist diagnosis, prognosis and therapy of multiple sclerosis.

SUBMITTER: Ryan FP

PROVIDER: S-EPMC3131726 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Human endogenous retroviruses in multiple sclerosis: potential for novel neuro-pharmacological research.

Ryan F P FP

Current neuropharmacology 20110601 2

There is growing evidence that the env genes of two or more human endogenous retroviruses (HERVs) of the W family are contributing to the inflammatory processes, and thus to the pathogenesis, of multiple sclerosis (MS). Increasing understanding of the human endogenous retroviral locus, ERVWE1, and the putative multiple sclerosis associated retrovirus, or MSRV, and in particular of the HERV-W env sequences associated with these, offers the potential of new lines of pharmacological research that m ...[more]

PMID: 22131944

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Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants?

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The monoclonal antibody GNbAC1: targeting human endogenous retroviruses in multiple sclerosis.

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Endogenous retroviruses and multiple sclerosis-new pieces to the puzzle.

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The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis.

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| S-EPMC9090245 | biostudies-literature

Demystified. Human endogenous retroviruses.

Project description:Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.

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