Ontology highlight
ABSTRACT:
SUBMITTER: Afanasyeva EA
PROVIDER: S-EPMC3131937 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Afanasyeva E A EA Mestdagh P P Kumps C C Vandesompele J J Ehemann V V Theissen J J Fischer M M Zapatka M M Brors B B Savelyeva L L Sagulenko V V Speleman F F Schwab M M Westermann F F
Cell death and differentiation 20110114 6
Several microRNA (miRNA) loci are found within genomic regions frequently deleted in primary neuroblastoma, including miR-885-5p at 3p25.3. In this study, we demonstrate that miR-885-5p is downregulated on loss of 3p25.3 region in neuroblastoma. Experimentally enforced miR-885-5p expression in neuroblastoma cell lines inhibits proliferation triggering cell cycle arrest, senescence and/or apoptosis. miR-885-5p leads to the accumulation of p53 protein and activates the p53 pathway, resulting in up ...[more]