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Synthesis of spiro-fused pyrazolidoylisoxazolines.

ABSTRACT: Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles. Molecular shape space diversity analyses were performed on these pyrazolidoylisoxazolines showing that manipulation of the appended R groups significantly changes the molecular shape.

SUBMITTER: Guggenheim KG

PROVIDER: S-EPMC3132818 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Synthesis of spiro-fused pyrazolidoylisoxazolines.

Guggenheim Kathryn G KG Butler Jeffrey D JD Painter Phillip P PP Lorsbach Beth A BA Tantillo Dean J DJ Kurth Mark J MJ

The Journal of organic chemistry 20110622 14

Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles. Molecular shape space diversity analyses were performed on these pyrazolidoylisoxazolines showing that manipulation of the appended R groups significantly changes the molecular shape. ...[more]

PMID: 21650164

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