Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.
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ABSTRACT:
SUBMITTER: Payne CM
PROVIDER: S-EPMC3132853 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
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Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.
Payne Claire M CM Crowley-Skillicorn Cheray C Bernstein Carol C Holubec Hana H Bernstein Harris H
Clinical and experimental gastroenterology 20110503
Chromosomal instability is a major pathway of sporadic colon carcinogenesis. Chromosome arm 1p appears to be one of the "hot spots" in the non-neoplastic mucosa that, when deleted, is associated with the initiation of carcinogenesis. Chromosome arm 1p contains genes associated with DNA repair, spindle checkpoint function, apoptosis, multiple microRNAs, the Wnt signaling pathway, tumor suppression, antioxidant activities, and defense against environmental toxins. Loss of 1p is dangerous since it ...[more]
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