Unstable tandem repeats in promoters confer transcriptional evolvability.
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ABSTRACT:
SUBMITTER: Vinces MD
PROVIDER: S-EPMC3132887 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Unstable tandem repeats in promoters confer transcriptional evolvability.
Vinces Marcelo D MD Legendre Matthieu M Caldara Marina M Hagihara Masaki M Verstrepen Kevin J KJ
Science (New York, N.Y.) 20090501 5931
Relative to most regions of the genome, tandemly repeated DNA sequences display a greater propensity to mutate. A search for tandem repeats in the Saccharomyces cerevisiae genome revealed that the nucleosome-free region directly upstream of genes (the promoter region) is enriched in repeats. As many as 25% of all gene promoters contain tandem repeat sequences. Genes driven by these repeat-containing promoters show significantly higher rates of transcriptional divergence. Variations in repeat len ...[more]
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