Ontology highlight
ABSTRACT:
SUBMITTER: Geng LN
PROVIDER: S-EPMC3132944 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Geng Linda N LN Tyler Ashlee E AE Tapscott Stephen J SJ
Hybridoma (2005) 20110401 2
Double homeobox 4 (DUX4) is a candidate disease gene for facioscapulohumeral dystrophy (FSHD), one of the most common muscular dystrophies characterized by progressive skeletal muscle degeneration. Despite great strides in understanding precise genetics of FSHD, the molecular pathophysiology of the disease remains unclear. One of the major limitations has been the availability of appropriate molecular tools to study DUX4 protein. In the present study, we report the development of five new monocl ...[more]