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Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides.

ABSTRACT: Deletion of Mycobacterium marinum MMAR2333 resulted in the loss of three of four subclasses of lipooligosaccharides (LOSs). The mutant was unable to extend an intermediate (LOS-II*) by addition of caryophyllose. These data and the predicted domain structure suggest that MMAR2333 is a glycosyltransferase involved in the generation of a lipid-linked caryophyllose donor.

SUBMITTER: Sarkar D

PROVIDER: S-EPMC3133064 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Identification of a glycosyltransferase from Mycobacterium marinum involved in addition of a caryophyllose moiety in lipooligosaccharides.

Sarkar Debasmita D Sidhu Mandeep M Singh Albel A Chen Jiemin J Lammas David A DA van der Sar Astrid M AM Besra Gurdyal S GS Bhatt Apoorva A

Journal of bacteriology 20110304 9

Deletion of Mycobacterium marinum MMAR2333 resulted in the loss of three of four subclasses of lipooligosaccharides (LOSs). The mutant was unable to extend an intermediate (LOS-II*) by addition of caryophyllose. These data and the predicted domain structure suggest that MMAR2333 is a glycosyltransferase involved in the generation of a lipid-linked caryophyllose donor. ...[more]

PMID: 21378187

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