Ontology highlight
ABSTRACT:
SUBMITTER: Hunt A
PROVIDER: S-EPMC3133377 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Hunt Aubrey A Fischer Melissa M Engel Michael E ME Hiebert Scott W SW
Molecular and cellular biology 20110502 13
Mtg16/Eto2 is a transcriptional corepressor that is disrupted by t(16;21) in acute myeloid leukemia. Using mice lacking Mtg16, we found that Mtg16 is a critical regulator of T-cell development. Deletion of Mtg16 led to reduced thymocyte development in vivo, and after competitive bone marrow transplantation, there was a nearly complete failure of Mtg16(-/-) cells to contribute to thymocyte development. This defect was recapitulated in vitro as Mtg16(-/-) Lineage(-)/Sca1(+)/c-Kit(+) (LSK) cells of ...[more]