Ontology highlight
ABSTRACT:
SUBMITTER: Ekim B
PROVIDER: S-EPMC3133410 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Ekim Bilgen B Magnuson Brian B Acosta-Jaquez Hugo A HA Keller Jennifer A JA Feener Edward P EP Fingar Diane C DC
Molecular and cellular biology 20110516 14
The mammalian target of rapamycin complex 1 (mTORC1) functions as an environmental sensor to promote critical cellular processes such as protein synthesis, cell growth, and cell proliferation in response to growth factors and nutrients. While diverse stimuli regulate mTORC1 signaling, the direct molecular mechanisms by which mTORC1 senses and responds to these signals remain poorly defined. Here we investigated the role of mTOR phosphorylation in mTORC1 function. By employing mass spectrometry a ...[more]