Ontology highlight
ABSTRACT:
SUBMITTER: Barbosa AD
PROVIDER: S-EPMC3133821 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Barbosa António Daniel AD Osório Hugo H Sims Kellie J KJ Almeida Teresa T Alves Mariana M Bielawski Jacek J Amorim Maria Amélia MA Moradas-Ferreira Pedro P Hannun Yusuf A YA Costa Vítor V
Molecular microbiology 20110628 2
Saccharomyces cerevisiae cells lacking Isc1p, an orthologue of mammalian neutral sphingomyelinase 2, display a shortened lifespan and an increased sensitivity to oxidative stress. A lipidomic analysis revealed specific changes in sphingolipids that accompanied the premature ageing of Isc1p-deficient cells under severe calorie restriction conditions, including a decrease of dihydrosphingosine levels and an increase of dihydro-C(26) -ceramide and phyto-C(26) -ceramide levels, the latter raising th ...[more]