Ontology highlight
ABSTRACT:
SUBMITTER: Mkhikian H
PROVIDER: S-EPMC3133923 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Nature communications 20110101
How environmental factors combine with genetic risk at the molecular level to promote complex trait diseases such as multiple sclerosis (MS) is largely unknown. In mice, N-glycan branching by the Golgi enzymes Mgat1 and/or Mgat5 prevents T cell hyperactivity, cytotoxic T-lymphocyte antigen 4 (CTLA-4) endocytosis, spontaneous inflammatory demyelination and neurodegeneration, the latter pathologies characteristic of MS. Here we show that MS risk modulators converge to alter N-glycosylation and/or ...[more]