Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology.
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ABSTRACT:
SUBMITTER: Ballas N
PROVIDER: S-EPMC3134296 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology.
Ballas Nurit N Lioy Daniel T DT Grunseich Christopher C Mandel Gail G
Nature neuroscience 20090222 3
The neurodevelopmental disorder Rett syndrome (RTT) is caused by sporadic mutations in the transcriptional factor methyl-CpG-binding protein 2 (MeCP2). Although it is thought that the primary cause of RTT is cell autonomous, resulting from a lack of functional MeCP2 in neurons, whether non-cell autonomous factors contribute to the disease is unknown. We found that the loss of MeCP2 occurs not only in neurons but also in glial cells of RTT brains. Using an in vitro co-culture system, we found tha ...[more]
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2019-08-02 | GSE135230 | GEO