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Pharmacokinetics, efficacy, and safety evaluation of docetaxel/hydroxypropyl-sulfobutyl-?-cyclodextrin inclusion complex.


ABSTRACT: Hydroxypropyl-sulfobutyl-?-cyclodextrin (HP-SBE-?-CD) inclusion complex was developed and used as a drug delivery system for DTX (DTX/HP-SBE-?-CD). The objective of the present study was to evaluate and compare the biological properties of DTX/HP-SBE-?-CD with Taxotere®. The pharmacokinetics, biodistribution, antitumor efficacy in vivo and in vitro, and safety evaluation of DTX/HP-SBE-?-CD were studied. The most significant finding was that it was possible to prepare a Polysorbate-80-free inclusion complex for DTX. Studies based on pharmacokinetics, biodistribution, and antitumor efficacy indicated that DTX/HP-SBE-?-CD had similar pharmacokinetic properties and antitumor efficacy both in vitro and in vivo as Taxotere®. Fortunately, this new drug delivery system attenuated the side effects when used in vivo. As a consequence, DTX/HP-SBE-?-CD may be a promising alternative to Taxotere® for cancer chemotherapy treatment with reduced side effects. The therapeutic potential against a variety of human tumors and low toxicity demonstrated in a stringent study clearly warrant clinical investigation of DTX/HP-SBE-?-CD for possible use against human tumors.

SUBMITTER: Huang XX 

PROVIDER: S-EPMC3134670 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Pharmacokinetics, efficacy, and safety evaluation of docetaxel/hydroxypropyl-sulfobutyl-β-cyclodextrin inclusion complex.

Huang Xing-Xing XX   Zhou Cheng-Liang CL   Wang Hui H   Chen Cheng C   Yu Shu-Qin SQ   Xu Qian Q   Zhu Yin-Yan YY   Ren Yong Y  

AAPS PharmSciTech 20110517 2


Hydroxypropyl-sulfobutyl-β-cyclodextrin (HP-SBE-β-CD) inclusion complex was developed and used as a drug delivery system for DTX (DTX/HP-SBE-β-CD). The objective of the present study was to evaluate and compare the biological properties of DTX/HP-SBE-Β-CD with Taxotere®. The pharmacokinetics, biodistribution, antitumor efficacy in vivo and in vitro, and safety evaluation of DTX/HP-SBE-β-CD were studied. The most significant finding was that it was possible to prepare a Polysorbate-80-free inclus  ...[more]

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