Ontology highlight
ABSTRACT:
SUBMITTER: Huang XX
PROVIDER: S-EPMC3134670 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Huang Xing-Xing XX Zhou Cheng-Liang CL Wang Hui H Chen Cheng C Yu Shu-Qin SQ Xu Qian Q Zhu Yin-Yan YY Ren Yong Y
AAPS PharmSciTech 20110517 2
Hydroxypropyl-sulfobutyl-β-cyclodextrin (HP-SBE-β-CD) inclusion complex was developed and used as a drug delivery system for DTX (DTX/HP-SBE-β-CD). The objective of the present study was to evaluate and compare the biological properties of DTX/HP-SBE-Β-CD with Taxotere®. The pharmacokinetics, biodistribution, antitumor efficacy in vivo and in vitro, and safety evaluation of DTX/HP-SBE-β-CD were studied. The most significant finding was that it was possible to prepare a Polysorbate-80-free inclus ...[more]