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The Case for the Use of PPAR? Agonists as an Adjunctive Therapy for Cerebral Malaria.

ABSTRACT: Cerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used. Adjunctive therapies that modify the pathophysiological processes caused by malaria are a possible way to improve outcome. This review focuses on the utility of PPAR? agonists as an adjunctive therapy for the treatment of cerebral malaria. The current knowledge of PPAR? agonist use in malaria is summarized. Findings from experimental CNS injury and disease models that demonstrate the potential for PPAR? agonists as an adjunctive therapy for cerebral malaria are also discussed.

SUBMITTER: Serghides L

PROVIDER: S-EPMC3135089 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria.

Serghides Lena L

PPAR research 20110609

Cerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used. Adjunctive therapies that modify the pathophysiological processes caused by malaria are a possible way to improve outcome. This review focuses on the utility of PPARγ agonists as an adjunctive therapy for the treatment of cerebral malaria. The current knowledge of PPARγ agonist use in malaria is summarized. Findings from experimenta ...[more]

PMID: 21772838

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