Ontology highlight
ABSTRACT:
SUBMITTER: Liu JJ
PROVIDER: S-EPMC3135476 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20110601 14
Activation of Rap1 small GTPases stabilizes cell--cell junctions, and this activity requires Krev Interaction Trapped gene 1 (KRIT1). Loss of KRIT1 disrupts cardiovascular development and causes autosomal dominant familial cerebral cavernous malformations. Here we report that native KRIT1 protein binds the effector loop of Rap1A but not H-Ras in a GTP-dependent manner, establishing that it is an authentic Rap1-specific effector. By modeling the KRIT1-Rap1 interface we designed a well-folded KRIT ...[more]