Ontology highlight
ABSTRACT:
SUBMITTER: Lee ST
PROVIDER: S-EPMC3135606 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Lee Soon-Tae ST Chu Kon K Jung Keun-Hwa KH Song Young-Mi YM Jeon Daejong D Kim Seung U SU Kim Manho M Lee Sang Kun SK Roh Jae-Kyu JK
PloS one 20110713 7
Neural stem cell (NSC) transplantation replaces damaged brain cells and provides disease-modifying effects in many neurological disorders. However, there has been no efficient way to obtain autologous NSCs in patients. Given that ectopic factors can reprogram somatic cells to be pluripotent, we attempted to generate human NSC-like cells by reprograming human fibroblasts. Fibroblasts were transfected with NSC line-derived cellular extracts and grown in neurosphere culture conditions. The cells we ...[more]