Ontology highlight
ABSTRACT:
SUBMITTER: Rufini A
PROVIDER: S-EPMC3135637 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Rufini Alessandro A Agostini Massimiliano M Grespi Francesca F Tomasini Richard R Sayan Berna S BS Niklison-Chirou Maria Victoria MV Conforti Franco F Velletri Tania T Mastino Antonio A Mak Tak W TW Melino Gerry G Knight Richard A RA
Genes & cancer 20110401 4
p73 is a tumor suppressor belonging to the p53 family of transcription factors. Distinct isoforms are transcribed from the p73 locus. The use of 2 promoters at the N-terminus allows the expression of an isoform containing (TAp73) or not containing (ΔNp73) a complete N-terminal transactivation domain, with the latter isoform capable of a dominant negative effect over the former. In addition, both N-terminal variants are alternatively spliced at the C-terminus. TAp73 is a bona fide tumor suppresso ...[more]