Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC3135732 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
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Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.
Wang Liying L Luanpitpong Sudjit S Castranova Vincent V Tse William W Lu Yongju Y Pongrakhananon Varisa V Rojanasakul Yon Y
Nano letters 20110609 7
Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of ...[more]
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