Nontraditional risk factors combine to predict Alzheimer disease and dementia.
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ABSTRACT: Objective
To investigate whether dementia risk can be estimated using only health deficits not known to predict dementia.Methods
A frailty index consisting of 19 deficits not known to predict dementia (the nontraditional risk factors index [FI-NTRF]) was constructed for 7,239 cognitively healthy, community-dwelling older adults in the Canadian Study of Health and Aging. From baseline, their 5-year and 10-year risks for Alzheimer disease (AD), dementia of all types, and survival were estimated.Results
The FI-NTRF was closely correlated with age (r2 > 0.96, p < 0.001). The incidence of AD and dementia increased exponentially with the FI-NTRF (r2 > 0.75, p < 0.001 over 10 years). Adjusted for age, sex, education, and baseline cognition, the odds ratio of dementia increased by 3.2% (p = 0.021) for each deficit (that was not known to predict dementia) accumulated, outperforming the individual cognitive risk factors. The FI-NTRF discriminated people with AD and all-cause dementia from those who were cognitively healthy with an area under the receiver operating characteristic curve of 0.66 ± 0.03.Conclusions
Comprehensive re-evaluation of a well-characterized cohort showed that age-associated decline in health status, in addition to traditional risk factors, is a risk factor for AD and dementia. General health may be an important confounder to consider in dementia risk factor evaluation. If a diverse range of deficits is associated with dementia, then improving general health might reduce dementia risk.
SUBMITTER: Song X
PROVIDER: S-EPMC3136058 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Nontraditional risk factors combine to predict Alzheimer disease and dementia.
Song Xiaowei X Mitnitski Arnold A Rockwood Kenneth K
Neurology 20110713 3
<h4>Objective</h4>To investigate whether dementia risk can be estimated using only health deficits not known to predict dementia.<h4>Methods</h4>A frailty index consisting of 19 deficits not known to predict dementia (the nontraditional risk factors index [FI-NTRF]) was constructed for 7,239 cognitively healthy, community-dwelling older adults in the Canadian Study of Health and Aging. From baseline, their 5-year and 10-year risks for Alzheimer disease (AD), dementia of all types, and survival w ...[more]
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