Ontology highlight
ABSTRACT:
SUBMITTER: Johnson RN
PROVIDER: S-EPMC3136133 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Johnson Russell N RN Kopecková Pavla P Kopecek Jindrich J
Bioconjugate chemistry 20090101 1
Several drug delivery designs combine synthetic drug carriers with covalently conjugated targeting moieties. Such modifications of monoclonal antibodies (mAb), or their Fab' fragments, inevitably result in diminished affinity for their targeted tissue. In an attempt to overcome this limitation, high molecular weight, branched N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesized and conjugated with Fab' fragments of the anti-CD20 antibody, 1F5. This produced multivalent conjugates ...[more]