Unknown

Dataset Information

0

Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation.

ABSTRACT: The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production of full-length proteins via the nonsense-mediated decay pathway still produce a majority of peptide substrates for the MHC class I pathway by a noncanonical mRNA translation process. Blocking the interaction of the translation initiation factor eIF4E with the cap structure suppresses the synthesis of full-length proteins but has only a limited effect on the production of antigenic peptides. These results reveal an essential cell biological function for a class of translation products derived during the pioneer round of mRNA translation and will have important implications for understanding how the immune system detects cells harboring pathogens and generates tolerance.

SUBMITTER: Apcher S 

PROVIDER: S-EPMC3136330 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation.

Apcher Sebastien S   Daskalogianni Chrysoula C   Lejeune Fabrice F   Manoury Bénédicte B   Imhoos Gabriela G   Heslop Lea L   Fåhraeus Robin R  

Proceedings of the National Academy of Sciences of the United States of America 20110627 28

The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production of full-length proteins via the nonsense-mediated decay pathway still produce a majority of peptide substrates for the MHC class I pathway by a noncanonical mRNA translation process. Blocking the inter  ...[more]

Similar Datasets

Transcriptomics Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
2005-04-01 | GSE2435 | GEO
Transcriptomics Altered binding of tumor antigenic peptides to MHC class I affects CD8 T cell effector responses
2018-10-06 | GSE120892 | GEO
Unknown Autophagy promotes MHC class II presentation of peptides from intracellular source proteins.
| S-EPMC1142372 | biostudies-literature
Unknown Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell-Effector Responses.
| S-EPMC6290996 | biostudies-literature
Unknown The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins.
| S-EPMC8643669 | biostudies-literature
Unknown Exosome-driven transfer of tumor-associated Pioneer Translation Products (TA-PTPs) for the MHC class I cross-presentation pathway.
| S-EPMC5048765 | biostudies-literature
Unknown Linkage of bacterial protein synthesis and presentation of MHC class I-restricted Listeria monocytogenes-derived antigenic peptides.
| S-EPMC3299774 | biostudies-literature
Unknown Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition.
| S-EPMC2453702 | biostudies-literature
Unknown Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self.
| S-EPMC2596764 | biostudies-literature
Unknown Translation of pre-spliced RNAs in the nuclear compartment generates peptides for the MHC class I pathway.
| S-EPMC3816435 | biostudies-literature