Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XM
PROVIDER: S-EPMC3136492 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Zhang Xue-Mei XM Zhong Rong R Liu Li L Wang Ying Y Yuan Ju-Xiang JX Wang Peng P Sun Chuang C Zhang Zhi Z Song Wen-Guang WG Miao Xiao-Ping XP
PloS one 20110714 7
<h4>Background</h4>Over-expression and increased activity of cyclooxygenase (COX)-2 induced by smoking has been implicated in the development of cancer. This study aimed to explore the interaction between smoking and functional polymorphisms of COX-2 in modulation of gastric cardia adenocarcinoma (GCA) risk.<h4>Methods and findings</h4>Three COX-2 polymorphisms, including -1195G>A (rs689466), -765G>C (rs20417), and 587Gly>Arg (rs3218625), were genotyped in 357 GCA patients and 985 controls. In t ...[more]