Ontology highlight
ABSTRACT:
SUBMITTER: Malcolm HR
PROVIDER: S-EPMC3136789 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Malcolm Hannah R HR Heo Yoon-Young YY Elmore Donald E DE Maurer Joshua A JA
Biophysical journal 20110701 2
Mutations that alter the phenotypic behavior of the Escherichia coli mechanosensitive channel of small conductance (MscS) have been identified; however, most of these residues play critical roles in the transition between the closed and open states of the channel and are not directly involved in lipid interactions that transduce the tension response. In this study, we use molecular dynamic simulations to predict critical lipid interacting residues in the closed state of MscS. The physiological r ...[more]