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Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese.

ABSTRACT: Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.

SUBMITTER: Okochi T 

PROVIDER: S-EPMC3137171 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese.

Okochi T T   Kishi T T   Ikeda M M   Kitajima T T   Kinoshita Y Y   Kawashima K K   Okumura T T   Tsunoka T T   Fukuo Y Y   Inada T T   Yamada M M   Uchimura N N   Iyo M M   Sora I I   Ozaki N N   Ujike H H   Iwata N N  

Current neuropharmacology 20110301 1

Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder,  ...[more]

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