Ontology highlight
ABSTRACT:
SUBMITTER: Liu YI
PROVIDER: S-EPMC3137263 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Liu Yan I YI Chang Mikyung V MV Li Hui E HE Barolo Scott S Chang Jinhee L JL Blauwkamp Tim A TA Cadigan Ken M KM
Developmental biology 20080822 1
The highly conserved Wingless/Wnt signaling pathway controls many developmental processes by regulating the expression of target genes, most often through members of the TCF family of DNA-binding proteins. In the absence of signaling, many of these targets are silenced, by mechanisms involving TCFs that are not fully understood. Here we report that the chromatin remodeling proteins ISWI and ACF1 are required for basal repression of WG target genes in Drosophila. This regulation is not due to glo ...[more]