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ABSTRACT:
SUBMITTER: Lipkin JS
PROVIDER: S-EPMC3137378 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Lipkin Jacob S JS Song Rui R Fenlon Edward E EE Brewer Scott H SH
The journal of physical chemistry letters 20110601 2
Vibrational reporters have shown significant promise as sensitive probes of local environments in proteins and nucleic acids. The utility of two potential vibrational probes, the cyanate and azide groups in phenyl cyanate and 3-azidopyridine, respectively, has been hindered by accidental Fermi resonance. Anharmonic coupling, between the fundamental -OCN or -N(3) asymmetric stretch vibration with a near resonant combination band, results in an extremely broad and complex absorption profile for ea ...[more]