Ontology highlight
ABSTRACT:
SUBMITTER: Borsani O
PROVIDER: S-EPMC3137516 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Borsani Omar O Zhu Jianhua J Verslues Paul E PE Sunkar Ramanjulu R Zhu Jian-Kang JK
Cell 20051201 7
In higher eukaryotes, miRNAs and siRNAs guide translational inhibition, mRNA cleavage, or chromatin regulation. We found that the antisense overlapping gene pair of Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), a stress-related gene, and SRO5, a gene of unknown function, generates two types of siRNAs. When both transcripts are present, a 24-nt siRNA is formed by a biogenesis pathway dependent on DCL2, RDR6, SGS3, and NRPD1A. Initial cleavage of the P5CDH transcript guided by the 24-nt ...[more]