IL-25 induces M2 macrophages and reduces renal injury in proteinuric kidney disease.
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ABSTRACT:
SUBMITTER: Cao Q
PROVIDER: S-EPMC3137571 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
IL-25 induces M2 macrophages and reduces renal injury in proteinuric kidney disease.
Cao Qi Q Wang Changqi C Zheng Dong D Wang Ya Y Lee Vincent W S VW Wang Yuan Min YM Zheng Guoping G Tan Thian Kui TK Yu Di D Alexander Stephen I SI Harris David C H DC Wang Yiping Y
Journal of the American Society of Nephrology : JASN 20110630 7
The kidney contains receptors for the cytokine IL-25, but the effects of IL-25 in CKD are unknown. Here, we induced adriamycin nephropathy in both BALB/c mice and severe combined immunodeficient (SCID) mice, and we injected IL-25 for 7 consecutive days starting at day 5 after adriamycin administration. BALB/c mice treated with IL-25 had less glomerulosclerosis, tubular atrophy, interstitial expansion, and proteinuria than control mice at day 28. IL-25 increased the levels of IL-4 and IL-13 in se ...[more]
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